Herbs Used in Antimalarial Medicines: A Study in the Greater Accra Region of Ghana.

Methods: Pharmacy shops were randomly scouted and products were observed. The active ingredients were documented and their frequencies were determined. Results: Forty-four (44) plant species belonging to twenty-eight (28) families were recorded for the treatment of malaria in the survey. The predominant families were the Leguminosae and Meliaceae families. Cryptolepis sanguinolenta (Ghanaian quinine or yellow dye root) and Azadirachta indica (neem tree) were the most cited plants. Cryptolepis and neem tree were used 17 and 15 times, respectively, in the finished herbal products for treating malaria. Conclusion. Cryptolepis sanguinolenta and Azadirachta indica (neem tree) are important herbs for the treatment of malaria in Ghana. Locally manufactured herbal antimalarials are important for the treatment of malaria in urban and rural communities in Ghana.

Exploration of factors influencing court outcomes in cases involving minors as victims in Ghana.

BACKGROUND: The factors that influence positive court outcomes for cases of child sexual abuse (CSA) have been studied in other contexts but very few such studies exist for Sub-Saharan countries. Knowledge of how such cases fare in these court systems is, however, important for a global assessment of such outcomes. OBJECTIVE: The study explored the predictive effect of the victim, complainant; offender and offence characteristics, and length of the trial on case disposition and dropout. METHODS, PARTICIPANTS AND SETTING: Three hundred and eighty-nine (389) closed court files related to child sexual abuse in Ghana were reviewed and analyzed. RESULTS: The findings show that the number of court sittings (length of trial) and complainant characteristics predict negative outcomes for CSA cases in Ghana. Specifically, convictions were less likely to occur where caregivers were the complainants (OR = 0.45), and when there were longer court sittings (OR = 0.95). Victim, offender, and offence characteristics, however, did not influence case outcomes. CONCLUSIONS: This study is one of the first studies using actual court data to predict the outcome of cases in CSA in Ghana, and makes recommendations for the support of children and caregivers through the court process.

In Vitro Anthelmintic Activity of Ethanol Stem Bark Extract of Albizia ferruginea (Guill. & Perr.) Benth.

Albizia ferruginea (Guill. & Perr.) Benth bark is used in the traditional medicine as a vermifuge. This study sought to determine the anthelmintic activity of the stem bark extract of Albizia ferruginea. The powdered A. ferruginea stem bark was extracted with ethanol. Phytochemical screening was carried out on A. ferruginea ethanol extract (AFE) and then screened for its anthelmintic property against Pheretima posthuma and Haemonchus contortus using the adult motility assay. The effect of AFE and its fractions on the anthelminthic activity of mebendazole and albendazole were also determined using the adult worm (P. posthuma) motility assay. AFE showed a dose-dependent anthelmintic activity against P. posthuma and H. contortus. The least concentration of AFE (0.5 mg/mL) paralyzed and killed P. posthuma within 272.50 ± 12.42 min and 354.50 ± 5.06 min of exposure, respectively. AFE at the least test concentration (0.14 mg/mL) caused paralysis and induced death of H. contortus, after at 63.50 ± 2.98 and 254.96 ± 2.44 min of exposure, respectively. AFE extract at 0.25 and 0.125 mg/mL increased the paralytic and helminthicidal activities of albendazole. The paralytic and helminthicidal activities of mebendazole were reduced when combined with AFE (0.25 and 0.125 mg/mL). Among the three fractions obtained from AFE, the methanol fraction showed the highest anthelmintic activity. The methanol fraction at 0.5 mg/mL caused paralysis after 69.90 ± 0.15 min and death of worm after 92.53 ± 0.74 min of exposure. The petroleum ether and ethyl acetate fractions showed relatively low anthelmintic activity. Phytochemical screening of AFE revealed the presence of tannins, saponins, glycosides, alkaloids, and coumarins. The results from this study show that A. ferruginea possesses anthelmintic activity which gives credence to its folkloric use.